Molecular Formula | C11H9NO5S |
Molar Mass | 267.25786 |
Density | 1.416±0.06 g/cm3(Predicted) |
Melting Point | 124-126°C |
Boling Point | 443.8±40.0 °C(Predicted) |
Solubility | DMSO: soluble20mg/mL, clear |
Appearance | powder |
Color | white to beige |
Storage Condition | Sealed in dry,Store in freezer, under -20°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
In vitro study | NSC697923 selectively inhibits PMA-induced NF-κB activation and also inhibits IκBα phosphorylation through RANKL and LPS. NSC697923 impedes the formation of UBC13 and ubiquitin thioester conjugates and inhibits NF-κB activity in ABC-DLBCL cells. In addition, NSC697923 inhibits proliferation and survival of ABC-DLBCL and GCB-DLBCL cells, and causes apoptosis in primary DLBCL cells. In the neuroblastoma cell line, NSC697923 exhibited cytotoxic effects and inhibited both adherent and non-adherent colony formation. |
In vivo study | NSC697923(5 mg/kg/day I. P.) showed strong antitumor efficacy in NB SH-SY5Y and NGP xenografts. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
WGK Germany | 3 |
biological activity | NSC697923 is a cell-selective permeable Ub-conjugating enzyme (E2) complex Ubc13-Uev1A inhibitor. |